The synthesis of a catalyst is a key step in determining its final structure, properties and performance. Every stage of the preparation process can strongly influence the resulting catalytic material, making the careful design and control of the synthesis procedure essential. Our approach combines the targeted development of specific catalyst properties with broader considerations of scalability, reproducibility and sustainability. Alongside conventional preparation methods, such as impregnation and precipitation, our group is exploring innovative synthetic strategies aimed at achieving a more precise control of the interaction between the active phase and the support. A major focus of our research is mechanochemical synthesis, particularly for the deposition and incorporation of metal species at the surface and subsurface of oxide supports. We are also developing thermally stable, high-surface-area materials designed to preserve their structural and functional properties under demanding reaction conditions. These approaches offer new opportunities to strengthen metal–support interactions, control the local environment of active sites and ultimately enhance catalytic activity, selectivity and stability. The optimization of catalyst synthesis is guided by a continuous feedback loop between materials preparation, advanced characterization and catalytic testing, allowing us to establish meaningful relationships between synthesis, structure and catalytic performance.